Atherosclerosis results from the accumulation of fat and cholesterol in the artery wall, leading to plaque that causes narrowing and hardening of the arteries, resulting in a loss of elasticity and function.

The image illustrates the progression of atherosclerosis.  As the disease progresses, the patient develops more severe coronary artery disease (CAD) resulting in increased risk of morbidity and death. Resverlogix is developing technologies to address all stages of CAD.