Investors

Jun 13, 2011

TSX Exchange Symbol: RVX

CALGARY, June 13, 2011 /CNW/ - Resverlogix Corp. ("Resverlogix" or the "Company") (TSX:RVX) announced today that the Company has completed its chronic repeated-dose toxicology studies on its lead compound, RVX-208, indicated for the reduction and prevention of atherosclerosis.  These chronic toxicology studies support the initiation of its longer duration, Phase IIb, clinical trial ASSURE. As a first-in-class compound, RVX-208 underwent six and twelve month testing in rodents and non-rodents, respectively, and the analysis, results and reporting of these studies to the appropriate regulatory authorities, have been completed.

With the safety studies complete, RVX-208 can now advance into trials of more than three months duration. The Phase IIb ASSURE trial, in which Intra Vascular Ultra Sound (IVUS) technology will be used to determine coronary arterial plaque regression, will have a treatment duration of six months.  The IVUS measurement will be used as the trial's primary endpoint.

Results from the recently completed ASSERT trial strongly demonstrate that RVX-208 is efficacious in elevating new production of ApoA-1, the key protein in 'good cholesterol', HDL cholesterol and HDL Alpha1 sub particles. None of these reverse cholesterol transport biomarkers appear to have reached their plateaus at the completion of that 12 week trial. As a result, Resverlogix was required by the FDA rules to complete the safety studies in order to progress to a six month human clinical study.

Resverlogix has identified more than 60 clinical sites in eight countries that will participate in the ASSURE trial study.  The Cleveland Clinic will serve as the trial co-manager and coordinate all data management and readouts of the primary endpoint. Countries with secured trial sites are located in both Europe and South America. With the completion of these chronic repeated-dose toxicology studies, Resverlogix has commenced the required national approval filings.  Upon completion of regulatory filings in each specific country, Resverlogix will then commence enrollment and dosing procedures.

"We are pleased to have completed and filed the data associated with the repeated-dose toxicology studies and that the trial is progressing according to timelines that we had previously discussed," said Donald J. McCaffrey, Resverlogix President and Chief Executive Officer.

The ASSURE trial is a placebo-controlled, double-blind intervention trial designed by Resverlogix in conjunction with the Cleveland Clinic and the Clinical Steering Committee, consisting of Drs. Steve Nissen, John Kastelein, Christie Ballantyne,  Phil Barter, and  principal investigator Dr. Stephen Nicholls. The trial patient population will be selected from patients referred for coronary angiography who meet selected angiographic criteria. Approximately 310 patients will participate, of which 77 will receive placebo and 233 will receive RVX-208 treatment.  Clinical trial information will be posted on www.Clinicaltrials.gov prior to first dosing.

Webcast Announcement:  In additional news Resverlogix Corp. will host a live Analyst teleconference and webcast on Tuesday, June 21^st at 11:00am Mountain time.  The purpose of the teleconference is to provide a market update from management regarding clinical trial developments. The dial-in numbers for this event will be 1-800-319-4610 and international 1-604-638-5340. A link for this webcast will be posted onto the homepage of Resverlogix' website and can be accessed from the following address
http://services.choruscall.com/links/resverlogix110613.html .

The webcast will be available on the Resverlogix website for a period of 45 days after the event.

About RVX-208

RVX-208, a novel small molecule therapeutic that facilitates endogenous ApoA-1 production, is positioned to be one of the most promising emerging drugs in the treatment of atherosclerosis. To the Company's knowledge RVX-208 is the only novel small molecule that is specifically designed to increase ApoA-I production and thereby raise HDL levels thus enhancing HDL functionality to augment reverse cholesterol transport (RCT). RCT is a pathway by which accumulated cholesterol is transported from the arterial wall to the liver for excretion, thus reducing or preventing atherosclerosis.

About Resverlogix Corp.
Resverlogix Corp. is a leading biotechnology company engaged in the development of novel therapies for important global medical markets with significant unmet medical needs. The NexVas PR program is the Company's primary focus which is to develop novel small molecules that enhance ApoA-1 production. These vital therapies are focused to address the burden of atherosclerosis and other important diseases such as Acute Coronary Syndrome, Diabetes, Alzheimer's disease, Peripheral Artery Disease and other vascular disorders. Resverlogix Corp.'s common shares trade on the Toronto Stock Exchange (TSX:RVX). For further information please visit www.resverlogix.com.

This news release may contain certain forward-looking information as defined under applicable Canadian securities legislation, including our statements with respect to research, development and commercialization of novel therapeutics that reduce the risk of cardiovascular disease, the conduct of the ASSURE trial and statements contained herein that are not based on historical fact, including without limitation statements containing the words "believes", "anticipates", "plans", "intends", "will", "should", "expects", "continue", "estimate", "forecasts" and other similar expressions. Our actual results, events or developments could be materially different from those expressed or implied by these forward-looking statements. We can give no assurance that any of the events or expectations will occur or be realized. By their nature, forward-looking statements are subject to numerous known and unknown risks and uncertainties including but not limited to those risk factors discussed in the Company's Annual Information Form and January 31, 2011 MD&A which are incorporated herein by reference and other documents we file from time to time with securities authorities, which are available through SEDAR at www.sedar.com. The forward-looking statements contained in this news release are expressly qualified by this cautionary statement are made as of the date hereof. The Company disclaims any intention and has no obligation or responsibility, except as required by law, to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.